Advancing Empty/Full Capsid Separation Technologies to Increase Potent Product Yield & Minimize Manufacturing Costs
1:45 pm - Wednesday 24th February 2027
- Evaluating novel chromatography resins and purification modalities to improve separation of genome containing versus non-genome-containing capsids, reducing the significant product losses that drive up cost per dose
- Implementing emerging analytical technologies including mass photometry, nanomosaic and analytical ultracentrifugation (AUC) for enhanced empty/full characterization to support regulatory filing confidence and process optimization
- Optimizing purification strategies to achieve higher purity levels while maintaining acceptable recovery rates and infectious titer, delivering more doses per batch for improved patient access
