Harnessing Integrated DOE Strategies Across Upstream & Downstream Development to Maximize AAV Productivity
9:30 am - Wednesday 24th February 2027
- Implementing carefully designed DOE studies during transfection development to increase AAV productivity while maintaining process robustness
- Incorporating full-to-empty capsid ratio considerations during upstream optimization to simplify downstream purification and improve product quality
- Connecting upstream process decisions with downstream empty/full separation strategies to increase development success and overall manufacturing efficiency
