Overcoming Impurity Challenges Downstream in Viral Vector Production: Advances in Purification & Analytical Techniques
Time: 3:00 pm
day: Conference Day One
Details:
- Discuss the challenges associated with removing empty capsids and other impurities in viral vector production, emphasizing their impact on therapeutic efficacy
- Explore advancements in purification methods, moving away from traditional ultracentrifugation to more efficient techniques that support high-purity vector production at scale
- Examine the development of high-throughput, sensitive assays for deep characterization of viral vectors, focusing on critical quality attributes (CQAs) such as genome integrity, potency, and the identification of various impurities, particularly during scale-up processes
