Round Table Discussion: Enhancing Efficacy through Reduced Immunogenicity with Innovative Capsid Designs
Time: 1:30 pm
day: Conference Day One
Details:
- Capsid Engineering Techniques: Cutting-edge methodologies, such as rational design and directed evolution, enable strategic modifications to AAV capsids for improved immune evasion and targeting
- Reduced Immunogenicity: Tailored capsid modifications can significantly diminish immunogenic epitope presentation, reducing T and B cell activation and enhancing the efficacy of AAV vectors in gene therapy
- Improved Delivery Efficiency: Engineered variants like PHP.B/eB AAV not only lower immunogenicity but also enhance delivery across the blood-brain barrier, crucial for effective treatments of neurological conditions
