David Knop
VP Cell Line & Process Development Asklepios BioPharmaceutical, Inc. (AskBio)
Seminars
Thursday 26th February 2026
Roundtable Discussion: Triple Transfection, Transient Systems, or Stable Cell Lines – Which Pathway Best Supports Commercialization?
12:30 pm
- Comparing triple transfection and transient systems for their ability to rapidly support early-stage programs, while evaluating their scalability limits at clinical and commercial scales
- Exploring how plasmid-heavy approaches create supply challenges at large scale, and whether dual plasmid systems or stable cell lines can reduce dependency on GMP plasmid supply
- Debating which transfection or cell line strategy best supports PPQ runs, regulatory alignment, and robust COGs to ensure long-term viability of gene therapies
Wednesday 25th February 2026
Roundtable Discussion: De-Risking Raw & Starting Material Supply: Building Flexible, Standardized, & Resilient Strategies for Viral Vector Manufacturing
9:30 am
- Extending supply chain risk mapping to strengthen continuity of critical raw and starting materials
- Exploring collaborative inventory models to bridge shortages and prevent delays to batch release and clinical timelines
- Standardizing materials across products to streamline inventory, lower cost and accelerate procurement
