Matt Edwards
Vice President - Process Science Affinia Therapeutics
I am an accomplished AAV process development leader and a seasoned CMC project manager with extensive experience spanning multiple stages of drug discovery, from target identification to IND filing. I have successfully led cross-functional program teams through drug development, from discovery to IND submission. My passion is leveraging my expertise to advance novel therapies, ensuring they reach patients in need.
Seminars
Wednesday 25th February 2026
Streamlining AAV Manufacturing with Novel-Plasmid Systems to Reduce Variability, Boost Productivity, & Accelerate Clinical Delivery
3:15 pm
- Reducing complexity in upstream workflows: assessing the potential for novel plasmid systems to streamline production
- Presenting insights from Affinia’s adoption of a novel plasmid system – Improving VG titres and reproducibility across capsid serotypes
- Discussing how a novel plasmid system can reduce GMP plasmid demand, simplify raw material supply chains, and lower COGs – directly accelerating time-to-clinic for rare disease programs
- Evaluating potential for scaling up through transfection volume, process timing and control
