Rekha Iyengar

Company: Stanford University

Job title: Senior Scientist Upstream Vector Development

Seminars:

Round Table Discussion: Enhancing Efficacy through Reduced Immunogenicity with Innovative Capsid Designs 1:30 pm

Capsid Engineering Techniques: Cutting-edge methodologies, such as rational design and directed evolution, enable strategic modifications to AAV capsids for improved immune evasion and targeting Reduced Immunogenicity: Tailored capsid modifications can significantly diminish immunogenic epitope presentation, reducing T and B cell activation and enhancing the efficacy of AAV vectors in gene therapy Improved Delivery Efficiency: Engineered…Read more

day: Conference Day One

Optimizing Viral Vector Production: Balancing High Titers and Maintaining Potency 9:30 am

Maximizing Viral Yields Without Sacrificing Quality: Strategies for increasing vector production, such as cell line engineering and process optimization, while minimizing the formation of defective particles Controlling Capsid Ratios for Consistency: Ensuring the proper empty-to-full capsid ratio to maintain viral vector potency and reduce risks related to immunogenicity and safety Addressing Impurities and Vector Purity:…Read more

day: Conference Day One