Optimizing Anion Exchange Chromatography Strategies to Enhance AAV Empty-Full Capsid Separation Efficiency

• Establishing anion exchange chromatography as a critical purification strategy to maximize empty-full capsid separation across AAV manufacturing processes
• Comparing multiple anion exchange chromatography approaches to select the most effective strategy for specific AAV process requirements
• Aligning anion exchange method selection with serotype characteristics, impurity load and partial capsid distribution to improve purification performance

Speakers:

Andrew Tustian

Executive Director, Preclinical Manufacturing & Process Development

Regeneron Pharmaceuticals