Sheldon Mink

Sheldon Mink

Company: Regeneron

Job title: Associate Director Viral Production Core


Characterization & modelling of single-use chromatographic clarification to replace endonuclease treatment in downstream processing of recombinant adeno-associated viral vectors 9:00 am

Current manufacturing processes for recombinant adeno-associated viral vectors (rAAV), endonuclease treatment is used prior to depth filtration to break down large amounts of chromatin post-cellular lysis of the HEK293 host cells. Single-use chromatographic clarification uses a next-generation synthetic fibrous anionexchange clarification media to simultaneously remove (i) solids through filtration, (ii) soluble negatively charged impurities, and…Read more

day: Conference Day 1 - AM

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